Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Furin sustains tumor-promoting signals in KRAS- and BRAF-mutated colorectal cancer by engaging the TGF-β1-COX-2 axis in a reciprocal regulatory network.

Oncogene - 1 Sept 2026

Liu Yiyang, Siegfried Géraldine, Pernot Simon, He Zongsheng, Martin Bornez Marta, Tejpar Sabine, Castanet Fanny, Desolneux Gregoire, Evrard Serge, Steinmetzer Torsten, Creemers John W M, Khatib Abdel-Majid

Abstract excerpt

KRAS and BRAF mutations drive colorectal cancer (CRC) progression by sustaining aberrant signaling and promoting therapeutic resistance. Here, we identify TGF-β1-COX-2 axis as a critical regulatory pathway mediated by Furin in CRC harboring KRAS or BRAF mutation. Genetic silencing or pharmacological inhibition of Furin in KRAS-mutant (KPN) and BRAF-mutant (BPN) tumor-derived cells suppressed tumor growth, reduced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclooxygenase 2

Share to Gene Expression Regulation, Neoplastic

Share to Proto-Oncogene Proteins B-raf

Share to Proto-Oncogene Proteins p21(ras)

Share to Transforming Growth Factor beta1

Source

Identifiers

PMID: 42437824
DOI: 10.1038/s41388-026-03875-w

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Furin sustains tumor-promoting signals in KRAS- and BRAF-mutated colorectal cancer by engaging the TGF-β1-COX-2 axis in a reciprocal regulatory network.PMID 42437824Read ↗

Furin sustains tumor-promoting signals in KRAS- and BRAF-mutated colorectal cancer by engaging the TGF-β1–COX-2 axis in a reciprocal regulatory networkSemantic proximity Read ↗

The proprotein convertase furin is a pro-oncogenic driver in KRAS and BRAF driven colorectal cancer.Semantic proximity Read ↗

Furin-like enzyme dependency in KRAS-mutant colorectal cancer as a target for personalized treatment strategies.Semantic proximity Read ↗

Cutting Edge: ERK1 Mediates the Autocrine Positive Feedback Loop of TGF-β and Furin in Glioma-Initiating CellsSemantic proximity Read ↗

The Impact of Cancer-Associated Fibroblasts on the Biology and Progression of Colorectal CarcinomasSemantic proximity Read ↗

NF-κB and apoptosis: colorectal cancer progression and novel strategies for treatmentSemantic proximity Read ↗

Inhibition of the BMP pathway suppresses tumor growth via downregulation of EGFR in MEK/ERK-dependent colorectal cancerSemantic proximity Read ↗

Acquired resistance to BRAF inhibitory treatments requires tumor tissue remodeling and reveals targetable vulnerabilities in colorectal cancerSemantic proximity Read ↗

Wnt5a suppresses colorectal cancer progression via TGF-β/NOTUM/OLFM4 axis in patient-derived organoidsSemantic proximity Read ↗

RGL2 Drives the Metastatic Progression of Colorectal Cancer via Preventing the Protein Degradation of β-catenin and KRASSemantic proximity Read ↗

THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancerSemantic proximity Read ↗

MEK inhibition suppresses metastatic progression of KRAS-mutated gastric cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.