Article

HYL001, a new potent TGFβ signaling inhibitor that is efficacious against microsatellite stable CRC metastasis in combination with immune checkpoint therapy in mice

2024-05-14

Abstract excerpt

<h4>ABSTRACT</h4> Blockade of the TGFβ signalling pathway has emerged from preclinical studies as a potential treatment to enhance the efficacy of immune checkpoint inhibition in advanced colorectal cancer (CRC) and several other types of cancer. However, clinical translation of first-generation inhibitors has known little success. Here, we report the synthesis and characterization of HYL001, a potent inhibitor o...

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Literature Corpus work: 1f135814-105a-57dd-b2c9-80642405961b
DOI: 10.1101/2024.05.10.593510

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