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System-wide transcriptome damage and tissue identity loss in COVID-19 patients

24 Jan 2022

Abstract excerpt

The molecular mechanisms underlying the clinical manifestations of coronavirus disease 2019 (COVID-19), and what distinguishes them from common seasonal influenza virus and other lung injury states such as acute respiratory distress syndrome, remain poorly understood. To address these challenges, we combine transcriptional profiling of 646 clinical nasopharyngeal swabs and 39 patient autopsy tissues to define...

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PMID: 35233546
DOI: 10.1016/j.xcrm.2022.100522

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