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Intravenous AAV9 efficiently transduces myenteric neurons in neonate and juvenile mice

15 Oct 2014

Abstract excerpt

Our recent discovery that adeno-associated virus type 9 (AAV9) can cross the blood brain barrier holds promise for the treatment of global neurological disease. Early studies with AAV9 gene therapy focused on transduction within the brain and spinal cord, but intravenous infusion results in widespread vector dissemination. Therapies for neurological diseases with autonomic or gastrointestinal involvement may...

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PMID: 25360081
DOI: 10.3389/fnmol.2014.00081

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