Article

Enhancer AAVs for targeting spinal motor neurons and descending motor pathways in rodents and macaque

2024-07-31

Abstract excerpt

<h4>Summary</h4> Experimental access to cell types within the mammalian spinal cord is severely limited by the availability of genetic tools. To enable access to lower motor neurons (LMNs) and LMN subtypes, we generated single cell multiome datasets from mouse and macaque spinal cords and discovered putative enhancers for each neuronal population. We cloned these enhancers into adeno-associated viral vectors (AAV...

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Identifiers and source

Literature Corpus work: 75047d32-3ea3-53dd-959a-6bd12fe17de7
DOI: 10.1101/2024.07.30.605864

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