Article
The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease.
Human molecular genetics - 1 Jan 2007
Kimura Ryo, Kamino Kouzin, Yamamoto Mitsuko, Nuripa Aidaralieva, Kida Tomoyuki, Kazui Hiroaki, Hashimoto Ryota, Tanaka Toshihisa, Kudo Takashi, Yamagata Hidehisa, Tabara Yasuharu, Miki Tetsuro, Akatsu Hiroyasu, Kosaka Kenji, Funakoshi Eishi, Nishitomi Kouhei, Sakaguchi Gaku, Kato Akira, Hattori Hideyuki, Uema Takeshi, Takeda Masatoshi
Abstract excerpt
We scanned throughout chromosome 21 to assess genetic associations with late-onset Alzheimer disease (AD) using 374 Japanese patients and 375 population-based controls, because trisomy 21 is known to be associated with early deposition of beta-amyloid (Abeta) in the brain. Among 417 markers spanning 33 Mb, 22 markers showed associations with either the allele or the genotype frequency (P < 0.05). Logistic...
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