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Article

Tumour neoantigen mimicry by microbial species in cancer immunotherapy.

British journal of cancer - 1 Aug 2021

Boesch Maximilian, Baty Florent, Rothschild Sacha I, Tamm Michael, Joerger Markus, Früh Martin, Brutsche Martin H

Abstract excerpt

Tumour neoantigens arising from cancer-specific mutations generate a molecular fingerprint that has a definite specificity for cancer. Although this fingerprint perfectly discriminates cancer from healthy somatic and germline cells, and is therefore therapeutically exploitable using immune checkpoint blockade, gut and extra-gut microbial species can independently produce epitopes that resemble tumour neoantigens...

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Identifiers

PMID: 33824481
DOI: 10.1038/s41416-021-01365-2
PMCID: PMC8329167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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