Article

Lipedema as a Syndrome of Adipose Mast Cell Activation and Type 2 Immune Orchestration: A Testable Neuroimmune Framework

2026-05-18

Abstract excerpt

Lipedema affects an estimated 11–12% of women worldwide and is characterized by bilateral, symmetric adipose deposition in the lower extremities, disproportionate pressure pain, spontaneous bruising, and resistance to conventional dietary interventions. Despite its prevalence, lipedema lacks a unifying mechanistic framework. Current descriptions treat it as a fat storage disorder with secondary vascular and inflam...

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Literature Corpus work: eff10d8d-5d1f-517e-82fe-78f95701a170
DOI: 10.20944/preprints202605.1114.v1

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