Article

An Adipose Mast-Cell Activation and Type-2 Orchestration Endotype of Lipedema: A Testable Neuroimmune Framework

2026-07-03

Abstract excerpt

Lipedema affects an estimated 11 to 12% of women and is characterized by bilateral, symmetric, painful enlargement of the limb subcutaneous fat that resists dietary weight loss. Its primary substrate is increasingly understood to be adipo-vascular and connective: genome-wide association studies implicate adipose, vascular, and extracellular-matrix loci rather than immune genes, and the affected fat is metabolicall...

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Literature Corpus work: a181a710-b3c0-5de6-aec5-ad03aee3559d
DOI: 10.20944/preprints202605.1114.v2

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