Article

Antidepressant and antipsychotic drugs reduce viral infection by SARS-CoV-2 and fluoxetine show antiviral activity against the novel variants <i>in vitro</i>

2021-03-23

Abstract excerpt

<h4>Background and Purpose</h4> Repurposing of currently available drugs is a valuable strategy to tackle the consequences of COVID-19. Recently, several studies have investigated the effect of psychoactive drugs on SARS-CoV-2 in cell culture models as well as in clinical practice. Our aim was to expand these studies and test some of these compounds against newly emerged variants. <h4>Experimental Approach</h4>...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: efe21578-b3f3-5a1e-96f0-e396e914b190
DOI: 10.1101/2021.03.22.436379

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Antidepressant and antipsychotic drugs reduce viral infection by SARS-CoV-2 and fluoxetine show antiviral activity against the novel variants <i>in vitro</i>DOI 10.1101/2021.03.22.436379Read

Computational drug re-purposing targeting the spike glycoprotein of SARS-CoV-2 as an effective strategy to neutralize COVID-19Semantic proximity Read

Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infectionSemantic proximity Read

Fluoxetine and Sertraline Potently Neutralize the Replication of Distinct SARS-CoV-2 VariantsSemantic proximity Read

Atorvastatin effectively inhibits late replicative cycle steps of SARS-CoV-2 <i>in vitro</i>Semantic proximity Read

Doxycycline inhibition of a pseudotyped virus transduction does not translate to inhibition of SARS-CoV-2 infectivitySemantic proximity Read

Broad antiviral effects of <i>Echinacea purpurea</i> against SARS-CoV-2 variants of concern and potential mechanism of actionSemantic proximity Read

Discovery of re-purposed drugs that slow SARS-CoV-2 replication in human cellsSemantic proximity Read

The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2Semantic proximity Read

Repurposing Cilnidipine as an Entry Inhibitor Against Crimean–Congo Haemorrhagic Fever Pseudovirus InfectionSemantic proximity Read

Efficient culture of SARS-CoV-2 in human hepatoma cells enhances viability of the virus in human lung cancer cell lines permitting the screening of antiviral compoundsSemantic proximity Read

Identification and evaluation of the inhibitory effect of Prunella vulgaris extract on SARS-coronavirus 2 virus entry.Semantic proximity Read

Methylene blue, Mycophenolic acid, Posaconazole, and Niclosamide inhibit SARS-CoV-2Omicron variant BA.1 infection of human airway epithelial explant culturesSemantic proximity Read