Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection

29 Jul 2021

Abstract excerpt

Patients with cardiovascular comorbidities are more susceptible to severe infection with SARS-CoV-2, known to directly cause pathological damage to cardiovascular tissue. We outline a screening platform using human embryonic stem cell-derived cardiomyocytes, confirmed to express the protein machinery critical for SARS-CoV-2 infection, and a SARS-CoV-2 spike-pseudotyped virus system. The method has allowed us to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to CRISPR and Genetic Engineering
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34326460
DOI: 10.1038/s42003-021-02453-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infectionPMID 34326460Read ↗

Human iPSC-Derived Cardiomyocytes Are Susceptible to SARS-CoV-2 InfectionSemantic proximity Read ↗

SARS-CoV-2 Infects Human Pluripotent Stem Cell-Derived Cardiomyocytes, Impairing Electrical and Mechanical FunctionSemantic proximity Read ↗

Parallel use of pluripotent human stem cell lung and heart models provide new insights for treatment of SARS-CoV-2Semantic proximity Read ↗

Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Platform to Study SARS-CoV-2 Related Myocardial InjurySemantic proximity Read ↗

Doxycycline inhibition of a pseudotyped virus transduction does not translate to inhibition of SARS-CoV-2 infectivitySemantic proximity Read ↗

Inhibitors of SARS-CoV‑2 Entry: Current and Future OpportunitiesSemantic proximity Read ↗

Identification of Potent Small Molecule Inhibitors of SARS-CoV-2 EntrySemantic proximity Read ↗

SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytesSemantic proximity Read ↗

Establishing a Disease‐in‐a‐Dish Model to Study SARS‐CoV‐2 Infection During Prenatal DevelopmentSemantic proximity Read ↗

Discovery of re-purposed drugs that slow SARS-CoV-2 replication in human cellsSemantic proximity Read ↗

SARS-CoV-2 Viral Genes Compromise Survival and Functions of Human Pluripotent Stem Cell-derived Cardiomyocytes via Reducing Cellular ATP LevelSemantic proximity Read ↗

Antitarget, Anti-SARS-CoV-2 Leads, Drugs, and the Drug Discovery–Genetics Alliance PerspectiveSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.