Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification and evaluation of the inhibitory effect of Prunella vulgaris extract on SARS-coronavirus 2 virus entry.

PloS one - 1 Jan 2021

Ao Zhujun, Chan Mable, Ouyang Maggie Jing, Olukitibi Titus Abiola, Mahmoudi Mona, Kobasa Darwyn, Yao Xiaojian

Abstract excerpt

Until now, antiviral therapeutic agents are still urgently required for treatment or prevention of SARS-coronavirus 2 (SCoV-2) virus infection. In this study, we established a sensitive SCoV-2 Spike glycoprotein (SP), including an SP mutant D614G, pseudotyped HIV-1-based vector system and tested their ability to infect ACE2-expressing cells. Based on this system, we have demonstrated that an aqueous extract from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiotensin-Converting Enzyme 2
Share to Antibodies, Neutralizing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chlorocebus aethiops

Share to COVID-19 Drug Treatment

Share to Plant Extracts

Share to SARS-CoV-2

Share to Spike Glycoprotein, Coronavirus

Share to Virus Internalization

Source

Open in PubMed Open full text

Identifiers

PMID: 34106944
DOI: 10.1371/journal.pone.0251649
PMCID: PMC8189562

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification and evaluation of the inhibitory effect of Prunella vulgaris extract on SARS-coronavirus 2 virus entry.PMID 34106944Read ↗

In silico screening of known small molecules to bind ACE2 specific RBD on Spike glycoprotein of SARS-CoV-2 for repurposing against COVID-19Semantic proximity Read ↗

Emerging Strains Of SARS-Cov2 And Their Inhibition by The Use of Phytochemicals: An In-Silico AnalysisSemantic proximity Read ↗

The Pan-African Natural Products Library Compounds Oleanolic Acid, Poinsettifolin B, and Rhuschalcone III Disrupt SARS-CoV-2 Spike-Host ACE2 Interactions and SARS-CoV-2 ReplicationSemantic proximity Read ↗

Inhibitors of SARS-CoV‑2 Entry: Current and Future OpportunitiesSemantic proximity Read ↗

Screening of Botanical Drugs against SARS-CoV-2 EntrySemantic proximity Read ↗

Existing Antiviral Options Against SARS-CoV-2 Replication in COVID-19 PatientsSemantic proximity Read ↗

Shortlisting Phytochemicals Exhibiting Inhibitory Activity against Major Proteins of SARS-CoV-2 through Virtual ScreeningSemantic proximity Read ↗

Identification of Potent Small Molecule Inhibitors of SARS-CoV-2 EntrySemantic proximity Read ↗

Discovery and Evaluation of Entry Inhibitors for SARS-CoV-2 and Its Emerging Variants.Semantic proximity Read ↗

High throughput screening identifies broad-spectrum Coronavirus entry inhibitorsSemantic proximity Read ↗

Significant Broad Spectrum Antiviral activity of Bi121 Against Different Variants of SARS-CoV-2Semantic proximity Read ↗

The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2 in vitroSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.