Article

Discovery of re-purposed drugs that slow SARS-CoV-2 replication in human cells

2021-02-01

Abstract excerpt

<h4>ABSTRACT</h4> COVID-19 vaccines based on the Spike protein of SARS-CoV-2 have been developed that appear to be largely successful in stopping infection. However, vaccine escape variants might arise leading to a re-emergence of COVID. In anticipation of such a scenario, the identification of repurposed drugs that stop SARS-CoV-2 replication could have enormous utility in stemming the disease. Here, using a nan...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c199ada6-a5fa-5cbd-b63f-4e6d07d0f1c2
DOI: 10.1101/2021.01.31.428851

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Discovery of re-purposed drugs that slow SARS-CoV-2 replication in human cellsDOI 10.1101/2021.01.31.428851Read

Identification of potential treatments for COVID-19 through artificial intelligence-enabled phenomic analysis of human cells infected with SARS-CoV-2Semantic proximity Read

Repositioning Ivermectin for Covid-19 treatment: Molecular mechanisms of action against SARS-CoV-2 replicationSemantic proximity Read

Computational drug re-purposing targeting the spike glycoprotein of SARS-CoV-2 as an effective strategy to neutralize COVID-19Semantic proximity Read

Preclinical and Clinical Study of Efficacy of NAOQ19 against SARS-COV2: A Comprehensive EvaluationSemantic proximity Read

Tripartite combination of potential pandemic mitigation agents: Vitamin D, Quercetin, and Estradiol manifest properties of candidate medicinal agents for mitigation of the severity of pandemic COVID-19 defined by genomics-guided tracing of SARS-CoV-2 targets in human cells.Semantic proximity Read

Inhibitors of SARS-CoV‑2 Entry: Current and Future OpportunitiesSemantic proximity Read

Molecular Mechanisms of the Medicines for COVID-19Semantic proximity Read

Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infectionSemantic proximity Read

Identification of Broad Anti-Coronavirus Chemical Agents for Repurposing Against SARS-CoV-2 and Variants of ConcernSemantic proximity Read

A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19Semantic proximity Read

Focusing on the Unfolded Protein Response and Autophagy Related Pathways to Reposition Common Approved Drugs against COVID-19Semantic proximity Read

Navigating the COVID-19 Therapeutic Landscape: Unveiling Novel Perspectives on FDA-Approved Medications, Vaccination Targets, and Emerging Novel StrategiesSemantic proximity Read