Article

Ependymomas are cancers of the pre-neural crest/roof plate lineage

2026-07-14

Abstract excerpt

Distinct molecular variants of the brain cancer ependymoma are distributed along the rostral-caudal extent of the central nervous system (CNS). Historically proposed to arise from ventricular ependyma, recent studies have suggested conflicting cellular origins, including the neural radial glia and the roof plate lineages. Using single-cell transcriptomics, immunohistochemistry, and lineage tracing, we demonstrate...

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Literature Corpus work: 770bc586-35ed-5af1-9488-b53d85862b7b
DOI: 10.64898/2026.07.13.736818

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