Cross-species genomics matches driver mutations and cell compartments to model ependymoma.

doi:10.1038/nature09173

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Article

Cross-species genomics matches driver mutations and cell compartments to model ependymoma.

Nature - 29 Jul 2010

Johnson Robert A, Wright Karen D, Poppleton Helen, Mohankumar Kumarasamypet M, Finkelstein David, Pounds Stanley B, Rand Vikki, Leary Sarah E S, White Elsie, Eden Christopher, Hogg Twala, Northcott Paul, Mack Stephen, Neale Geoffrey, Wang Yong-Dong, Coyle Beth, Atkinson Jennifer, DeWire Mariko, Kranenburg Tanya A, Gillespie Yancey, Allen Jeffrey C, Merchant Thomas, Boop Fredrick A, Sanford Robert A, Gajjar Amar, Ellison David W, Taylor Michael D, Grundy Richard G, Gilbertson Richard J

Abstract excerpt

Understanding the biology that underlies histologically similar but molecularly distinct subgroups of cancer has proven difficult because their defining genetic alterations are often numerous, and the cellular origins of most cancers remain unknown. We sought to decipher this heterogeneity by integrating matched genetic alterations and candidate cells of origin to generate accurate disease models. First, we...

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PMID: 20639864
DOI: 10.1038/nature09173
PMCID: PMC2912966

Genes

EPHB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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