Developmental Effects of the ToxCast™ Phase I and Phase II Chemicals in <i>Caenorhabditis elegans</i> and Corresponding Responses in Zebrafish, Rats, and Rabbits

Abstract excerpt

BACKGROUND: Modern toxicology is shifting from an observational to a mechanistic science. As part of this shift, high-throughput toxicity assays are being developed using alternative, nonmammalian species to prioritize chemicals and develop prediction models of human toxicity. METHODS: The nematode Caenorhabditis elegans (C. elegans) was used to screen the U.S. Environmental Protection Agency's (EPA's) ToxCast™...

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