Article

Klf4 overexpression remodels chromatin to reprogram late retinal progenitors toward a retinal ganglion cell-like fate

2026-07-02

Abstract excerpt

Developing neuron-replacement therapies for retinal ganglion cells (RGCs) lost to injury or disease requires a deeper understanding of how restriction to cell identity acquisition may be overcome. Previously, we showed that overexpression of Klf4 in late retinal progenitor cells (late RPCs), which are normally restricted from RGC production, is sufficient to produce cells that display a subset of canonical RGC pr...

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Literature Corpus work: ef839652-5ac0-56d8-84e7-f7aef7c8e40c
DOI: 10.64898/2026.06.28.734840

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