Article

Genome wide screen of RNAi molecules against SARS-CoV-2 creates a broadly potent prophylaxis

2022-04-12

Abstract excerpt

Expanding the arsenal of prophylactic approaches against SARS-CoV-2 is of utmost importance, specifically those strategies that are resistant to antigenic drift in Spike. Here, we conducted a screen with over 16,000 RNAi triggers against the SARS-CoV-2 genome using a massively parallel assay to identify hyper-potent siRNAs. We selected 10 candidates for in vitro validation and found five siRNAs that exhibited hyp...

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Identifiers and source

Literature Corpus work: 64ba527f-4c60-5d22-8eb3-1491a682b488
DOI: 10.1101/2022.04.12.488010

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