Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis.

doi:10.1056/NEJMoa1013068

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Article

Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis.

The New England journal of medicine - 18 Aug 2011

Marrakchi Slaheddine, Guigue Philippe, Renshaw Blair R, Puel Anne, Pei Xue-Yuan, Fraitag Sylvie, Zribi Jihen, Bal Elodie, Cluzeau Céline, Chrabieh Maya, Towne Jennifer E, Douangpanya Jason, Pons Christian, Mansour Sourour, Serre Valérie, Makni Hafedh, Mahfoudh Nadia, Fakhfakh Faiza, Bodemer Christine, Feingold Josué, Hadj-Rabia Smail, Favre Michel, Genin Emmanuelle, Sahbatou Mourad, Munnich Arnold, Casanova Jean-Laurent, Sims John E, Turki Hamida, Bachelez Hervé, Smahi Asma

Abstract excerpt

BACKGROUND: Generalized pustular psoriasis is a life-threatening disease of unknown cause. It is characterized by sudden, repeated episodes of high-grade fever, generalized rash, and disseminated pustules, with hyperleukocytosis and elevated serum levels of C-reactive protein, which may be associated with plaque-type psoriasis. METHODS: We performed homozygosity mapping and direct sequencing in nine Tunisian...

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PMID: 21848462
DOI: 10.1056/NEJMoa1013068

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