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Article

Mutation in IL36RN impairs the processing and regulatory function of the interleukin-36-receptor antagonist and is associated with DITRA syndrome.

Experimental dermatology - 1 Oct 2019

Bal Elodie, Lim Ai Ching, Shen Min, Douangpanya Jason, Madrange Marine, Gazah Rihab, Tauber Marie, Beghdadi Walid, Casanova Jean Laurent, Bourrat Emmanuelle, Bachelez Hervé, Towne Jennifer E, Smahi Asma

Abstract excerpt

The identification of loss-of-function mutations of the IL36RN gene encoding the interleukin-36 receptor antagonist (IL-36Ra) in generalized pustular psoriasis (GPP) emphasized the key role of this pathway in skin innate immunity and systemic inflammation. It has been previously shown in vitro that removal of the N-terminal amino acid IL36Ra (M1) is critical to its biological activity, but the in vivo...

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PMID: 28603914
DOI: 10.1111/exd.13387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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