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Generalized pustular psoriasis: immunological mechanisms, genetics, and emerging therapeutics.

Trends in immunology - 1 Jan 2025

Lee Chih-Chun, Huang Yu-Huei, Chi Ching-Chi, Chung Wen-Hung, Chen Chun-Bing

Abstract excerpt

Generalized pustular psoriasis (GPP) is a rare human autoinflammatory disorder with life-threatening systemic effects. Keratinocyte-derived interleukin (IL)-36 signaling has been identified as a key mediator of immune response in the skin of affected individuals. Recognition of various mutations along the IL-36 axis and the downstream nuclear transcription factor κB (NF-κB) signaling have established GPP as...

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PMID: 39732527
DOI: 10.1016/j.it.2024.12.001

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