Article

Combined Metabolic Activators Improves Cognitive Functions in Alzheimer’s Disease

2021-07-20

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. Here, we analysed the brain transcriptomics data of more than 600 AD patients using genome-scale metabolic models and provided supporting evidence of mitochondrial dysfunction related to the pathophysiologic mechanisms of AD progression. Subsequently, we investigated, in a rat mod...

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Literature Corpus work: ef561963-31a2-508d-9cf7-1eaf9e358d07
DOI: 10.1101/2021.07.14.21260511

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