Matrix metalloproteinases and their biological function in human gliomas

Abstract excerpt

Gliomas, a type of devastating primary brain tumors, are distinct from other solid, non-neural primary neoplasms, in that they display extensive infiltrative invasive behavior but seldom metastasize to distant organs. This invasiveness into the surrounding normal brain tissue makes gliomas a major challenge for clinical intervention. Total surgical resection of gliomas is not possible, and recurrence of tumor...

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