A primate model organism for cardiac arrhythmias identifies a magnesium transporter in pacemaker function

Abstract excerpt

<h4>ABSTRACT</h4> Cardiac arrhythmias afflict tens of millions of people, causing one-fifth of all deaths 1 . Although mouse models have aided understanding of some pacemaker genes and arrhythmias 2,3 , mice are not known to naturally acquire arrhythmias, and the substantial differences between mouse and human cardiac anatomy and physiology have limited their utility in preclinical studies and pharmacological t...

Topics

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• Arrhythmias, Cardiac
• Cardiac electrophysiology and arrhythmias
• Death, Sudden, Cardiac
• Flecainide
• Mice
• Mutation
• Mutation, Missense
• Ryanodine Receptor Calcium Release Channel

Identifiers and source

Literature Corpus work

ef27e8b8-f443-55ec-80e6-fd0aa259dbb5

DOI

10.1101/2025.05.28.655959