Article

Effective Suppression of Hypoxia Induced Angiogenesis by Synergism of Simvastatin and Metformin via Inhibiting ET-1-ETBR-Hif1α Signaling Axis

2021-09-20

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Hypoxic stress accelerates metabolic reprogramming to promote malignant progression, which contains huge and interesting drug targets for cancer therapy. According to recently reports and our previously researches, simvastatin (SVA) or metformin (MET), two metabolic relevant drugs, play an important role in inhibiting tumor growth, angiogenesis, improvement hypo...

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Literature Corpus work: eee4aabe-b841-5cdd-90dc-8a5ce1ce38c0
DOI: 10.21203/rs.3.rs-885738/v1

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