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Article

Inhibitory effect of melatonin on hypoxia-induced vasculogenic mimicry via suppressing epithelial-mesenchymal transition (EMT) in breast cancer stem cells.

European journal of pharmacology - 15 Aug 2020

Maroufi Nazila Fathi, Amiri Maryam, Dizaji Babak Faraji, Vahedian Vahid, Akbarzadeh Maryam, Roshanravan Neda, Haiaty Sanya, Nouri Mohammad, Rashidi Mohammad-Reza

Abstract excerpt

Vasculogenic mimicry (VM) play an important role in breast cancer metastasis and anti- angiogenic drugs resistance. Hypoxia, the epithelial-mesenchymal transition (EMT), and cancer stem cells (CSCs) are known as essential factors for VM formation. Also, melatonin is an amino acid-derived hormone with many anti-tumor effects. Despite the antitumor effects of melatonin, its effect on VM formation in breast cancer...

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Identifiers

PMID: 32580038
DOI: 10.1016/j.ejphar.2020.173282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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