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Article

Role of Sirtuins in Tumor Angiogenesis

17 Jan 2020

Abstract excerpt

Changes in the metabolic status of cells under conditions like hypoxia and accumulation of lactate can be sensed by various sensing mechanisms which leads into modulation of number of signal transduction pathways and transcription factors. Tumors under hypoxic microenvironment secretes a number of proangiogenic cytokines like VEGF, FGF, PDGF, TGF-β, Ang-2, ILs etc. These cytokines binds to their receptors on the...

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PMID: 32010617
DOI: 10.3389/fonc.2019.01516

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