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Mechanisms of action of metformin and its regulatory effect on microRNAs related to angiogenesis

19 Dec 2020

Abstract excerpt

Angiogenesis is rapidly initiated in response to pathological conditions and is a key target for pharmaceutical intervention in various malignancies. Anti-angiogenic therapy has emerged as a potential and effective therapeutic strategy for treating cancer and cardiovascular-related diseases. Metformin, a first-line oral antidiabetic agent for type 2 diabetes mellitus (T2DM), not only reduces blood glucose levels...

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PMID: 33352227
DOI: 10.1016/j.phrs.2020.105390

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