Article

Endothelial Baf60c Alleviates Hyperoxia-Induced BPD-Associated Pulmonary Hypertension Through Smarcc2 and PI3K-Akt-mTOR Signaling

2026-07-01

Abstract excerpt

<h4>BACKGROUND</h4> Bronchopulmonary dysplasia–associated pulmonary hypertension (BPD-PH) complicates prematurity and carries substantial morbidity in extremely preterm infants. Pulmonary microvascular endothelial cell (PMVEC) dysfunction promotes capillary rarefaction and vascular remodeling, but epigenetic mechanisms after neonatal hyperoxia are poorly defined. Baf60c (SMARCD3), a SWI/SNF subunit supporting vas...

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Literature Corpus work: eee00b9d-de14-53cb-a949-2622b96aca1e
DOI: 10.64898/2026.06.26.734924

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