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Postnatal Alveologenesis Depends on FOXF1 Signaling in c-KIT+ Endothelial Progenitor Cells

24 Jun 2019

Abstract excerpt

Abstract Rationale Disruption of alveologenesis is associated with severe pediatric lung disorders, including bronchopulmonary dysplasia (BPD). Although c-KIT+ endothelial cell (EC) progenitors are abundant in embryonic and neonatal lungs, their role in alveolar septation and the therapeutic potential of these cells remain unknown. Objectives To determine whether c-KIT+ EC progenitors stimulate alveologenesis in...

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PMID: 31233341
DOI: 10.1164/rccm.201812-2312oc

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