Human-mouse cross-species comparison identifies common and unique aspects of intestinal mesenchyme development

Abstract excerpt

<h4>Summary</h4> Using single-cell RNA sequencing (scRNA-seq) and histological approaches, we examine cross-species cellular identity, diversity and organization of mesenchymal (fibroblast) populations in the developing mouse and human intestines. In both species, we defined 7 fibroblast populations. Using cross-species integration and label transfer approaches we find that each mesenchymal cell subtype in the mu...

Topics

Open a Topic to create a Post that cites this publication.

• Cancer Cells and Metastasis
• Disease
• Fibroblasts
• Gene Knock-In Techniques
• Organ Specificity
• RNA-Seq
• Single-Cell Analysis
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

eeb48736-47f4-54ed-b4a1-6c25cf0b4dc5

DOI

10.1101/2025.09.03.674033