Article

Resolving cell lineages and gene functions in the developing mouse gastrointestinal tract using <i>in utero</i> transduction

2026-04-13

Abstract excerpt

<h4>ABSTRACT</h4> How diverse cell lineages emerge and are genetically regulated during organogenesis are central questions in understanding the developmental origins of disease. However, the mouse gut, including its intrinsic enteric nervous system (ENS) derived from migratory neural crest, has remained difficult to experimentally target. Here, we introduce an in utero lentiviral nano-injection strategy that en...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9c16fcd3-29d0-5b52-8d48-fea84f1db736
DOI: 10.64898/2026.04.09.716777

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Resolving cell lineages and gene functions in the developing mouse gastrointestinal tract using <i>in utero</i> transductionDOI 10.64898/2026.04.09.716777Read

The gastrointestinal development ‘parts list’: transcript profiling of embryonic gut development in wildtype and <i>Ret</i> -deficient miceSemantic proximity Read

Human-mouse cross-species comparison identifies common and unique aspects of intestinal mesenchyme developmentSemantic proximity Read

Gene- and tissue-level interactions in normal gastrointestinal development and Hirschsprung diseaseSemantic proximity Read

Single cell transcriptomics reveals a signaling roadmap coordinating endoderm and mesoderm diversification during foregut organogenesisSemantic proximity Read

Mouse models of Hirschsprung disease and other developmental disorders of the enteric nervous system: Old and new playersSemantic proximity Read

Lineage dynamics of murine pancreatic development at single-cell resolutionSemantic proximity Read

Lentiviral labeling of mouse and human enteric nervous system stem cells for regenerative medicine studiesSemantic proximity Read

Quantitative lineage analysis identifies a long-term progenitor niche for the hepato-pancreato-biliary organ systemSemantic proximity Read

<i>Ret</i> loss-of-function decreases neural crest progenitor proliferation and restricts developmental fate potential during enteric nervous system developmentSemantic proximity Read

Cellular origins and lineage relationships of the intestinal epitheliumSemantic proximity Read

Regionalized cell and gene signatures govern oesophageal epithelial homeostasisSemantic proximity Read

ENS lineage potential is not intrinsically regionalized but is modulated by PTPRZ1 signalingSemantic proximity Read