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A Mouse Model of Melanoma Driven by Oncogenic KRAS

1 Jun 2010

Abstract excerpt

The small G-protein NRAS is mutated in 22% of human melanomas, whereas the related proteins KRAS and HRAS are mutated in only 2% and 1% of melanomas, respectively. We have developed a mouse model of melanoma in which Cre recombinase/LoxP technology is used to drive inducible expression of (G12V)KRAS in the melanocytic lineage. The mice develop skin hyperpigmentation, nevi, and tumors that bear many of the...

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PMID: 20516123
DOI: 10.1158/0008-5472.can-09-4254

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