Article
Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma.
Cancer discovery - 1 Dec 2014
Burd Christin E, Liu Wenjin, Huynh Minh V, Waqas Meriam A, Gillahan James E, Clark Kelly S, Fu Kailing, Martin Brit L, Jeck William R, Souroullas George P, Darr David B, Zedek Daniel C, Miley Michael J, Baguley Bruce C, Campbell Sharon L, Sharpless Norman E
Abstract excerpt
UNLABELLED: NRAS mutation at codons 12, 13, or 61 is associated with transformation; yet, in melanoma, such alterations are nearly exclusive to codon 61. Here, we compared the melanoma susceptibility of an NrasQ61R knock-in allele to similarly designed KrasG12D and NrasG12D alleles. With concomitant p16INK4a inactivation, KrasG12D or NrasQ61R expression efficiently promoted melanoma in vivo, whereas NrasG12D did...
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