Cleavage of MALAT1 RNA by 14-nt sgRNA-guided tRNase Z ^L

Abstract excerpt

We have been developing a gene suppression technology, tRNase Z L -utilizing efficacious (TRUE) gene silencing, in which artificially designed small guide RNA (sgRNA) guides tRNase Z L to cleave cellular target RNA. In this study, we examined 14-nt linear-type sgRNAs, which are fully 2′- O -methylated and have full phosphorothioate linkages, for their ability to suppress a level of a nuclear-localized long non-...

Topics

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• Advanced biosensing and bioanalysis techniques
• Alternative Splicing
• Cell Line, Tumor
• Cell Movement
• Lung Cancer Research Studies
• Lung Neoplasms
• Mice, Inbred BALB C
• RNA modifications and cancer

Identifiers and source

Literature Corpus work

d20b78b8-f54b-57cb-8c4b-ffb8afd5fd8a

DOI

10.1101/2025.01.28.635233