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Article

Differential dysregulation of CREB and synaptic genes in transgenic Drosophila melanogaster expressing shaggy (GSK3), TauWT, or Amyloid-beta

2022-09-01

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Tau,<bold> </bold>Amyloid-beta (Aβ<sub>42</sub>), and Glycogen synthase kinase 3 (GSK3) contribute to synaptic dysfunction observed in Alzheimer's disease (AD), the most common form of dementia. In the current study, the effect of pan-neuronal expression of Tau<sup>WT</sup>, Aβ<sub>42</sub>, or shaggy (orthologue of GSK3) in <italic>Drosophila melanogaster</ital...

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Literature Corpus work
ee781b0a-0a94-5db4-9ab5-f2e9b6e4e2e6
DOI
10.21203/rs.3.rs-2002030/v1
Open publication

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