Article

Role of IL-6 and ERα in the genotoxicity of environmental carcinogens in mammary cells

2016-01-01

Abstract excerpt

Worldwide, breast cancer is the most commonly diagnosed cancer in women. Inherited genes (15%) have a role in the prevalence of breast cancer while diet and lifestyle play major roles (around 85%). Environmental factors such as consumption of red or processed meat, cigarette smoke and inflammation are major risk factors of this disease. Despite the known breast cancer risk factors, the underlying mechanisms are no...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ee6218c3-f0be-508a-b220-dcfd152fb005
DOI: 10.25560/60849

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 11 closest

Role of IL-6 and ERα in the genotoxicity of environmental carcinogens in mammary cellsDOI 10.25560/60849Read

Relationships between cytokine (IL-6 and TGF-β1) gene polymorphisms and chromosomal damage in hospital workers.Semantic proximity Read

Environmental immune disruptors, inflammation and cancer riskSemantic proximity Read

Detection of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine-DNA adducts in normal breast tissues and risk of breast cancer.Semantic proximity Read

Genetic polymorphisms of phase I metabolizing enzyme genes, their interaction with lifetime grilled and smoked meat intake, and breast cancer incidence.Semantic proximity Read

Environmental exposure and the role of AhR in the tumor microenvironment of breast cancerSemantic proximity Read

Associations of polymorphisms in the cytokine genes IL1β (rs16944), IL6 (rs1800795), IL12b (rs3212227) and growth factor VEGFA (rs2010963) with anthracosilicosis in coal miners in Russia and related genotoxic effects.Semantic proximity Read

Bisphenol A disruption promotes mammary tumor microenvironment via phenotypic cell polarization and inflammatory response.Semantic proximity Read

Molecular and genetic toxicology of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).Semantic proximity Read

Perspectives on the chemical etiology of breast cancer.Semantic proximity Read

The food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine activates S-phase checkpoint and apoptosis, and induces gene mutation in human lymphoblastoid TK6 cells.Semantic proximity Read

Perfluoroalkyl substances promote breast cancer progression via ERα and GPER mediated PI3K/Akt and MAPK/Erk signaling pathwaysSemantic proximity Read