Article
Bisphenol A disruption promotes mammary tumor microenvironment via phenotypic cell polarization and inflammatory response.
Cell biology international - 1 Jun 2023
Ruiz Thalles F R, Colleta Simone J, Dos Santos Diego D, Castro Nayara F C, Cabral Ágata S, Calmon Marilia F, Rahal Paula, Gil Cristiane D, Girol Ana Paula, Vilamaior Patricia S L, Leonel Ellen C R, Taboga Sebastião R
Abstract excerpt
Inflammation in the established tumor microenvironment (TME) is often associated with a poor prognosis of breast cancer. Bisphenol A (BPA) is an endocrine-disrupting chemical that acts as inflammatory promoter and tumoral facilitator in mammary tissue. Previous studies demonstrated the onset of mammary carcinogenesis at aging when BPA exposure occurred in windows of development/susceptibility. We aim to...
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