Article
Associations of polymorphisms in the cytokine genes IL1β (rs16944), IL6 (rs1800795), IL12b (rs3212227) and growth factor VEGFA (rs2010963) with anthracosilicosis in coal miners in Russia and related genotoxic effects.
Mutagenesis - 13 Apr 2018
Volobaev Valentin P, Larionov Aleksey V, Kalyuzhnaya Ekaterina E, Serdyukova Ekaterina S, Yakovleva Svetlana, Druzhinin Vladimir G, Babich Olga O, Hill Elena G, Semenihin Victor A, Panev Nikolay I, Minina Varvara I, Sivanesan Saravana Devi, Naoghare Pravin, da Silva Juliana, Barcelos Gustavo R M, Prosekov Alexander Y
Abstract excerpt
Anthracosilicosis (AS), a prevalent form of pneumoconiosis among coal miners, results from the accumulation of carbon and silica in the lungs from inhaled coal dust. This study investigated genotoxic effects and certain cytokine genes polymorphic variants in Russian coal miners with АS. Peripheral leukocytes were sampled from 129 patients with AS confirmed by X-ray and tissue biopsy and from 164 asymptomatic coal...
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