Article

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol

2018-09-20

Abstract excerpt

<h4>ABSTRACT</h4> Lecithin:cholesterol acyltransferase (LCAT) and LCAT-activating small molecules are being investigated as treatments for coronary heart disease (CHD) and familial LCAT deficiency (FLD). Herein we report the crystal structure of LCAT bound to a potent activator and an acyl intermediate-like inhibitor, thereby revealing an active conformation of LCAT and that the activator is bound exclusively to...

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Literature Corpus work: ee46295f-5f88-53e0-8b45-f8303a72f631
DOI: 10.1101/422725

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