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Article

Activation of Naturally Occurring Lecithin:Cholesterol Acyltransferase Mutants by a Novel Activator Compound.

The Journal of pharmacology and experimental therapeutics - 1 Dec 2020

Pavanello Chiara, Ossoli Alice, Turri Marta, Strazzella Arianna, Simonelli Sara, Laurenzi Tommaso, Kono Keita, Yamada Keisuke, Kiyosawa Naoki, Eberini Ivano, Calabresi Laura

Abstract excerpt

Lecithin:cholesterol acyltransferase (LCAT) is a unique plasma enzyme able to esterify cholesterol, and it plays an important role in HDL maturation and promotion of reverse cholesterol transport. Familial LCAT deficiency (FLD; OMIM number 245900) is a rare recessive disease that results from loss-of-function mutations in the LCAT gene and has no cure. In this study, we assessed the in vitro efficacy of a novel...

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PMID: 32980814
DOI: 10.1124/jpet.120.000159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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