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Article

The high-resolution crystal structure of human LCAT.

Journal of lipid research - 1 Sept 2015

Piper Derek E, Romanow William G, Gunawardane Ruwanthi N, Fordstrom Preston, Masterman Stephanie, Pan Oscar, Thibault Stephen T, Zhang Richard, Meininger David, Schwarz Margrit, Wang Zhulun, King Chadwick, Zhou Mingyue, Walker Nigel P C

Abstract excerpt

LCAT is intimately involved in HDL maturation and is a key component of the reverse cholesterol transport (RCT) pathway which removes excess cholesterol molecules from the peripheral tissues to the liver for excretion. Patients with loss-of-function LCAT mutations exhibit low levels of HDL cholesterol and corneal opacity. Here we report the 2.65 Å crystal structure of the human LCAT protein. Crystallization...

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Share to Cholesterol
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phosphatidylcholine-Sterol O-Acyltransferase

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Source

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Identifiers

PMID: 26195816
DOI: 10.1194/jlr.M059873
PMCID: PMC4548775

Genes

LCAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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