Article

Ribonucleotide Reductase Subunit Switching in Hepatoblastoma Drug Response and Relapse

2023-01-24

Abstract excerpt

<h4>ABSTRACT</h4> Prognosis of children with high-risk hepatoblastoma (HB), the most common pediatric liver cancer, remains poor. In this study, we found ribonucleotide reductase (RNR) subunit M2 ( RRM2 ) was one of the key genes supporting cell proliferation in high-risk HB. While standard chemotherapies could effectively suppress RRM2 in HB cells, they induced a significant upregulation of the other RNR M2 sub...

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Literature Corpus work: cdcc344e-1104-5be7-8ab0-d184be6ec355
DOI: 10.1101/2023.01.24.525404

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