Article

Cerebrospinal fluid endo-lysosomal proteins as potential biomarkers for Huntington’s disease

2020-05-14

Abstract excerpt

Molecular markers derived from cerebrospinal fluid (CSF) represent an accessible means of exploring the pathobiology of Huntington’s disease (HD) in vivo. The endo-lysosomal/autophagy system is dysfunctional in HD, potentially contributing to disease pathogenesis and representing a potential target for therapeutic intervention. Several endo-lysosomal proteins have shown promise as biomarkers in other neurodegenera...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ee3cabda-ff8d-5d05-942b-c3dc5264239e
DOI: 10.1101/2020.05.14.095828

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cerebrospinal fluid endo-lysosomal proteins as potential biomarkers for Huntington’s diseaseDOI 10.1101/2020.05.14.095828Read

Cerebrospinal Fluid Biomarkers for Huntington’s DiseaseSemantic proximity Read

Analysis of Circulating Protein Aggregates Reveals Pathological Hallmarks of Amyotrophic Lateral SclerosisSemantic proximity Read

Analysis of circulating protein aggregates reveals pathological hallmarks of amyotrophic lateral sclerosisSemantic proximity Read

Comparisons of neurodegenerative disease biomarkers across different biological fluids from patients with Huntington’s diseaseSemantic proximity Read

Advances in Huntington’s Disease Biomarkers: A 10-Year Bibliometric Analysis and a Comprehensive ReviewSemantic proximity Read

Different CSF protein profiles in amyotrophic lateral sclerosis and frontotemporal dementia withC9orf72hexanucleotide repeat expansionSemantic proximity Read

Proteomic profiling of baseline CSF and serum from HDClarity identifies signatures for Huntington disease staging and stratificationSemantic proximity Read

What, When and How to Measure-Peripheral Biomarkers in Therapy of Huntington's Disease.Semantic proximity Read

Small peptide fingerprint (peptidomics) of Amyotrophic Lateral Sclerosis in CSFSemantic proximity Read

Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington’s disease patientsSemantic proximity Read

A Two-Track Model of Striatal Degeneration in Huntington’s Disease: Independent Contributions of Cytoskeletal Damage and Immune Dysregulation Consistent with an Immune-Exhaustion-Like ProfileSemantic proximity Read

Salivary levels of total huntingtin are elevated in Huntington’s disease patientsSemantic proximity Read