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Article

Tacrine is not an ideal probe drug for measuring CYP1A2 activity in vivo.

British journal of clinical pharmacology - 1 Nov 1999

Larsen J T, Hansen L L, Brosen K

Abstract excerpt

AIMS: The aim of the present study was to examine the CYP1A2 substrate tacrine as a possible alternative to caffeine for assessing CYP1A2 activity in vivo. METHODS: Eighteen, healthy, nonsmoking men participated. Each volunteer was tested by caffeine (200 mg orally), and caffeine metabolic ratios were calculated. Subsequently, on two occasions, separated by at least 4 weeks, each volunteer was tested with tacrine...

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Identifiers

PMID: 10594467
DOI: 10.1046/j.1365-2125.1999.00079.x
PMCID: PMC2014350

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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