Back to search

Article

Loss of <i>Bacteroides thetaiotaomicron</i> bile acid altering enzymes impact bacterial fitness and the global metabolic transcriptome

2023-06-27

Abstract excerpt

Bacteroides thetaiotaomicron ( B. theta ) is a Gram-negative gut bacterium that encodes enzymes that alter the bile acid pool in the gut. Primary bile acids are synthesized by the host liver and are modified by gut bacteria. B. theta encodes two bile salt hydrolases (BSHs), as well as a hydroxysteroid dehydrogenase (HSDH). We hypothesize that B. theta modifies the bile acid pool in the gut to provide a fitness...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
edc1eb50-5dc7-5e65-8b2c-23148f1cfb10
DOI
10.1101/2023.06.27.546749
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Loss of <i>Bacteroides thetaiotaomicron</i> bile acid altering enzymes impact bacterial fitness and the global metabolic transcriptomeDOI 10.1101/2023.06.27.546749
Loss of Bacteroides thetaiotaomicron bile acid-altering enzymes impacts bacterial fitness and the global metabolic transcriptomeSemantic proximity
A selective gut bacterial bile salt hydrolase alters host metabolismSemantic proximity
Large-scale chemical-genetics of the human gut bacterium <i>Bacteroides thetaiotaomicron</i>Semantic proximity
Functional genetics of human gut commensal Bacteroides thetaiotaomicron reveals metabolic requirements for growth across environments.Semantic proximity
The Black Box Orchestra of Gut Bacteria and Bile Acids: Who Is the Conductor?Semantic proximity
Bile acid fitness determinants of a <i>Bacteroides fragilis</i> isolate from a human pouchitis patientSemantic proximity
Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gutSemantic proximity
Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiomeSemantic proximity
Ecology and engineering to modify the bile acid output of a defined microbial communitySemantic proximity
Investigation and Alteration of Organic Acid Synthesis Pathways in the Mammalian Gut Symbiont Bacteroides thetaiotaomicronSemantic proximity
Bile salt hydrolase acyltransferase activity expands bile acid diversity.Semantic proximity
Bile salt hydrolase/aminoacyltransferase shapes the microbiomeSemantic proximity
Select a neighboring publication to make it the new centre.