Article

Large-scale chemical-genetics of the human gut bacterium <i>Bacteroides thetaiotaomicron</i>

2019-03-09

Abstract excerpt

The genomic catalogue of the human microbiota has expanded dramatically in recent years, and insights derived from human microbiota genomics has vast potential to generate treatments for human diseases. However, predictably harnessing the microbiota for beneficial outcomes is currently limited by our lack of understanding of the physiology of the constituent bacteria. For instance, the functions of most of their g...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8373b726-8d44-5437-bf43-af089c24c8e3
DOI: 10.1101/573055

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Large-scale chemical-genetics of the human gut bacterium <i>Bacteroides thetaiotaomicron</i>DOI 10.1101/573055Read

Functional genetics of human gut commensal Bacteroides thetaiotaomicron reveals metabolic requirements for growth across environments.Semantic proximity Read

Construction and characterization of a genome-scale ordered mutant collection of <i>Bacteroides thetaiotaomicron</i>Semantic proximity Read

A toolkit for transposon libraries and functional genomics in intestinal BacteroidalesSemantic proximity Read

Loss of <i>Bacteroides thetaiotaomicron</i> bile acid altering enzymes impact bacterial fitness and the global metabolic transcriptomeSemantic proximity Read

An integrated transcriptomics–functional genomics approach reveals a small RNA that modulates <i>Bacteroides thetaiotaomicron</i> sensitivity to tetracyclinesSemantic proximity Read

Dynamic genetic adaptation of Bacteroides thetaiotaomicron during murine gut colonizationSemantic proximity Read

A hybrid two-component system protein of a prominent human gut symbiont couples glycan sensing <i>in vivo</i> to carbohydrate metabolismSemantic proximity Read

Dynamic genetic adaptation of <i>Bacteroides thetaiotaomicron</i> murine gut colonizationSemantic proximity Read

Rapid genetic diversification of <i>Bacteroides thetaiotaomicron</i> in mono-associated mice revealed through deep population-level sequencingSemantic proximity Read

Loss of Bacteroides thetaiotaomicron bile acid-altering enzymes impacts bacterial fitness and the global metabolic transcriptomeSemantic proximity Read

Dual transposon sequencing (Dual Tn-seq) to probe genome-wide genetic interactionsSemantic proximity Read

Genetic determinants of in vivo fitness and diet responsiveness in multiple human gut BacteroidesSemantic proximity Read