Back to search

Article

Integrated Histopathology–Transcriptomic Biomarker Enhances Survival Prediction in HNSCC Patients Treated with Immunotherapy

2025-12-01

Abstract excerpt

Recurrent and metastatic head and neck squamous cell carcinoma (R/M HNSCC) remains a challenging disease with modest response to immune checkpoint inhibitors and a need for more robust predictive biomarkers. In a real-world (RW) cohort of patients treated with pembrolizumab alone or in combination with chemotherapy, we evaluated transcriptomic and histopathologic features associated with therapeutic benefit. PD-L1...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
edb49cbf-61d9-5234-b891-b30b5d4e493b
DOI
10.1101/2025.11.26.25341072
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Integrated Histopathology–Transcriptomic Biomarker Enhances Survival Prediction in HNSCC Patients Treated with ImmunotherapyDOI 10.1101/2025.11.26.25341072
Predictive and prognostic factors for immunotherapy response in head and neck squamous cell carcinoma: a narrative review.Semantic proximity
Integrative Models of Histopathological Image Features and Omics Data Predict Survival in Head and Neck Squamous Cell CarcinomaSemantic proximity
Histopathological image and gene expression pattern analysis for predicting molecular features and prognosis of head and neck squamous cell carcinoma.Semantic proximity
CD8 + T cell related prognostic risk model and tumor immune environment modulation in HNSCC based on single-cell and bulk RNA sequencingSemantic proximity
Identification of factors related to immunotherapy efficacy and prognosis in patients with advanced head and neck squamous cell carcinoma.Semantic proximity
Evaluation of Alcohol, Tobacco, and HPV’s Synergistic regulation of Head and Neck Squamous Cell Carcinoma Treatment Response to PD-L1 Checkpoint Inhibitor TreatmentSemantic proximity
Clinical-genomic determinants of immune checkpoint blockade response in head and neck squamous cell carcinoma.Semantic proximity
CT Radiomics-Clinical Model for Noninvasive Prediction of Tumor Mutation Burden and Survival in Locally Advanced Head and Neck Squamous Cell CarcinomaSemantic proximity
Integrative Spatial Analysis of H&E and IHC Images Identifies Prognostic Immune Subtypes Correlated with Progression-Free Survival in Human Papillomavirus (HPV)-Related Oropharyngeal Squamous Cell CarcinomaSemantic proximity
High-Sensitivity PD-L1 Staining Using Clone 73-10 Antibody and Spatial Transcriptomics for Precise Expression Analysis in Non-Tumorous, Intraepithelial neoplasia, and Squamous Cell Carcinoma of Head and NeckSemantic proximity
A Systematic Review on a comprehensive evaluation of clinical prognostic variables and new biomarkers for head and neck cancer outcomeSemantic proximity
Heterogeneity of PD-L1 expression on tumor cells and tumor-infiltrating immune cells between the primary tumor and matched lymph node metastases in head and neck squamous cell carcinomasSemantic proximity
Select a neighboring publication to make it the new centre.