Article
A feedback-loop between telomerase activity and stemness factors regulates PDAC stem cells
2020-11-03
Abstract excerpt
To date, it is still unclear how cancer stem cells (CSCs) regulate their stemness properties, and to what extent they share common features with normal stem cells. Telomerase regulation is a key factor in stem cell maintenance. In this study, we investigate how telomerase regulation affects cancer stem cell biology in pancreatic ductal adenocarcinoma (PDAC), and delineate the mechanisms by which telomerase activit...
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Identifiers and source
- Literature Corpus work
- ed8ccae2-2aa5-5d96-a74e-b75b150676f5
- DOI
- 10.1101/2020.11.02.361931