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Article

Acinar cell clonal expansion in pancreas homeostasis and carcinogenesis.

Nature - 1 Sept 2021

Neuhöfer Patrick, Roake Caitlin M, Kim Stewart J, Lu Ryan J, West Robert B, Charville Gregory W, Artandi Steven E

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer deaths worldwide1. Studies in human tissues and in mouse models have suggested that for many cancers, stem cells sustain early mutations driving tumour development2,3. For the pancreas, however, mechanisms underlying cellular renewal and initiation of PDAC remain unresolved. Here, using lineage tracing from the endogenous telomerase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34526722
DOI: 10.1038/s41586-021-03916-2
PMCID: PMC9347609

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